The Tigers suffered their first defeat of the new Premier League season as Manchester United scored a late, late goal to earn a 1-0 win at the KCOM Stadium.
Substitute Marcus Rashford struck in added time, converting Wayne Rooney’s low cross, to deliver a cruel blow after another big performance from the home side.
Mike Phelan named the same starting eleven as in last weekend’s win at Swansea.
A foul on Adama Diomande gave the Tigers an early free kick in a promising position as Robert Snodgrass set his sights. His effort was blocked by the wall before a follow up from Tom Huddlestone flew high over the bar.
United went close in the tenth minute when a cross from the left was met by the head of Zlatan Ibrahimovic, his effort going just over.
Marouane Fellaini picked up a yellow card as Diomande won another free kick in a dangerous position 24 minutes in. Snodgrass stepped up again and this time curled a shot just wide.
The two side looked well matched at this stage and a quick attack down the left from the Tigers almost brought the opening goal. Diomande teed Andy Robertson up for a cross to the far post that was brilliantly defended by Luke Shaw as Snodgrass challenged him.
Eldin Jakupovic made a couple of routine saves from distant efforts by Paul Pogba and Juan Mata with United finding a route into the home penalty box tough to find, while at the other end David De Gea held a Abel Hernandez header.
When United did make it into the Tigers’ box, they still hit a resilient barrier as Curtis Davies blocked a goalbound Rooney shot following good work out wide by Mata.
United went close again on the stroke of half time. Ibrahimovic got himself on the end of a Wayne Rooney free kick and took the ball out of Jakupovic’s path before back-heeling an effort into the side-netting from a tight angle.
Two minutes added on provided enough time for Hernandez to hit a low shot goalwards, but De Gea dealt with it comfortably.
The Tigers were forced into a change early in the second half when Snodgrass pulled up with an injury. He was replaced by Shaun Maloney.
United were enjoying the better possession and territory with Ibrahimovic seeing a low shot from the edge of the box deflect just wide.
Paul Pogba tried his luck from fully 30 yards out and wasn’t far off target with a shot that rose over the bar.
Tom Huddlestone picked up a first yellow card for the home side when he tripped substitute Henrikh Mkhitaryan as he threatened to cut a path straight through the middle of the Tigers’ defence.
Rooney flashed a low volley wide as a full-on thunderstorm set in at the KCOM before Huddlestone’s shot from the edge of the United box deflected just wide.
Huddlestone had another effort moments later, sending a dipping volley just over the bar.
Meyler was booked for a foul on Mkhitaryan as United were awarded a free kick a little over 20 yards from goal in the 78th minute, but Pogba could only send it wide.
Jakupovic made his first big save of the afternoon a couple of minutes later, pushing away a low Rashford shot that was heading for the bottom corner of the net and the goalkeeper had to be alert again when beating away Antonio Valencia’s deflected cross at the near post before some heroic defending from Curtis Davies blocked a Mkhitaryan effort.
The Tigers made a second change seven minutes from time when Harry Maguire came on for Hernandez.
With the clock ticking down, Pogba curled wide from the edge of the box and Jakupovic held a low shot from Mkhitaryan in what was now a game of United’s attack versus the Tigers’ defence.
Meyler had a chance for the Tigers as the game moved into added time, firing over from the edge of the area but there was to be late heartbreak as United broke the deadlock two minutes over the 90. Rooney got the better of Ahmed Elmohamady out wide and crossed low for Rashford to finish from close range.
It proved to be just about the last kick of the game, a cruel ending after another fine showing from the Tigers.
Hull City: Eldin Jakupovic, Ahmed Elmohamady, Jake Livermore, Curtis Davies, Andy Robertson, Sam Clucas, David Meyler, Tom Huddlestone, Robert Snodgrass (Shaun Maloney 48), Adama Diomande, Abel Hernandez (Harry Maguire 83).
Subs Not Used: Dusan Kuciak, Jarrod Bowen, Greg Olley, Josh Clackstone, Ben Hinchliffe.
Manchester United: David De Gea, Eric Bailly, Paul Pogba, Juan Mata (Marcus Rashford 71), Zlatan Ibrahimovic, Wayne Rooney (Chris Smalling 90), Anthony Martial (Henrikh Mkhitaryan 60), Daley Blind, Luke Shaw, Antonio Valencia, Marouane Fellaini.
Subs Not Used: Sergio Romero, Ashley Young, Ander Herrera, Morgan Schneiderlin.
Referee: Mr J. Moss.
Attendance: 24, 560 (2,319 Visiting Supporters).