Two of those changes come in the back four with Ryan Tafazolli and the fit-again Callum Elder replacing Jordy de Wijs and Matthew Pennington, while Josh Magennis and Josh Bowler start in place of Tom Eaves and Kamil Grosicki.
Eaves and Pennington are included on the bench along with new signings Martin Samuelsen and Mallik Wilks.
Former Tiger Tom Huddlestone starts for the home side, with Curtis Davies and Chris Martin amongst the substitutes.
Derby County: Ben Hamer, Andre Wisdom, Martyn Waghorn, Tom Lawrence, Matt Clarke, Duane Holmes, Max Lowe, Wayne Rooney, Jayden Bogle, Jason Knight, Tom Huddlestone.
Subs: Kelle Roos, Craig Forsyth, Chris Martin, Curtis Davis, Louie Sibley, Max Bird, Morgan Whittaker.
Hull City: George Long, Eric Lichaj, Ryan Tafazolli, Reece Burke, Josh Bowler, Jarrod Bowen, Callum Elder, Josh Magennis, Jackson Irvine, Leonardo Da Silva Lopes, Herbie Kane.
Subs: Matt Ingram, Dan Batty, Tom Eaves, George Honeyman, Matthew Pennington, Martin Samuelsen, Mallik Wilks.
Referee: Mr A. Woolmer