The Tigers had recovered from conceding early to lead 2-1 at the interval courtesy of goals from Jarrod Bowen and Kamil Grosicki, but substitute Joe Gelhardt fired in an equaliser 15 minutes from time to earn the visitors a point.
Callum Elder made his debut at left back as Grant McCann made three changes to the side that drew at Millwall before the international break. Elder came in for Matthew Penningron, while Reece Burke (injury) and Josh Magennis (suspended) were replaced by Ryan Tafazolli and Tom Eaves.
19-year-old Elliot Bonds, a recent signing for the Club’s U23 side, was named on the bench.
Former Tiger David Marshall started in goal for Wigan.
Wigan started the brighter and took the lead from an eighth-minute set-piece. Charlie Mulgrew delivered a free kick into the box and, when George Long failed to hold onto Kieffer Moore’s header, Cheyenne Dunkley was there to finish from close range.
The Wigan lead lasted just two minutes as the Tigers hit straight back to equalise. Grosicki played a square ball across the box for Bowen to finish from six yards at the second attempt.
Nathan Byrne picked up a booking for the visitors for taking down Grosicki as the Polish winger skipped past him looking to set up a second goal, which he netted himself from the resulting free kick. A superb effort beat the wall and then Marshall at his near post for 2-1 in the 20th minute.
Wigan skipper Sam Morsy picked up a yellow for a needless foul in the middle of the park before Tom Eaves had a chance to add a third goal for the home side when meeting Geroge Honeyman’s lovely cross to the far post but the striker headed over.
Eaves was then denied by Marshall in added time after getting the slightest of glances on Bowen’s cross and it remained 2-1 at the break.
Elder went close early in the second half as he rounded off a flowing move down the left with a shot that was turned wide by Marshall, while Kevin Stewart sent a drive wide from the edge of the box.
Grosicki was inches away from scoring from another free kick but was denied by a combination of Marshall and the post, with Eaves seeing his effort deflect into the side-netting from the rebound.
Grosicki was then booked for a foul on Byrne ahead of a first change that saw Leonardo Da Silva Lopes replace Honeyman.
Wigan drew level 15 minutes from time. Substitute Gelhardt was able to twist and turn inside the box before firing past Long.
A second change saw Josh Bowler replace Eaves in the final ten minutes and although the home side pushed for a winner, there were no further chances.
Hull City: George Long; Eric Lichaj ©, Jordy de Wijs, Ryan Tafazoli, Callum Elder; Kevin Stewart, George Honeyman (Leonardo Da Silva Lopes 71), Jackson Irvine; Jarrod Bowen, Kamil Grosicki, Tom Eaves (Josh Bowler 84).
Subs Not Used: Matt Ingram, Brandon Fleming, Matthew Pennington, Keane Lewis-Potter, Elliot Bonds.
Wigan Athletic: David Marshall, Samy Morsy, Cheyenne Dunkley, Charlie Mulgrew, Nathan Byrne, Antonee Robinson, Joe Williams, Gavin Massey (Joe Gelhardt 72), Michael Jabobs (Kal Naismith 90), Jamal Lowe, Kieffer Moore (Joe Garner 72).
Subs Not Used: Jamie Jones, Danny Fox, Lewis MacLeod, Lee Evans.
Referee: Mr G. Ward.