There were just two changes to the side that beat Bolton Wanderers a week earlier. Lucas Odunston came in at right-back for Robbie McKenzie and Lupano replaced Sean McLoughlin in the centre of defence. Up front Norbert Balogh continued his comeback from injury.
The Tigers had an early scare when David Robson picked up what was harshly judged to be a back pass but Tom Allan could only fire the resulting free-kick wide from a narrow angle off target and out for a throw-in.
City’s best chance of the opening period came when Balogh’s pass released Ahmed Salam but his shot was held by Magpies keeper Jake Turner.
The hosts took the lead from a 37th minute penalty when Kell Watts went down under a challenge by Matty Jacob and Thomas Allan converted from the spot to give the hosts a one-goal lead at the break.
James Berry fired over early in the second half before Lupano headed over from a Callum Jones corner as the Tigers tried to find a way back into the game.
Robson made a good low save to deny Allan whilst at the other end Turner pushed away Balogh’s shot with Oliver Walters completing the clearance.
Newcastle had a great opportunity to double their lead from Allan’s low cross but Elias Sorensen put his effort over the crossbar as he slid in. Victor Fernandez had the next chance for Newcastle but Robson tipped his effort away.
And the hosts were made to pay for their missed chances when the Tigers drew level in the 66th minute. A cross from the left was headed back across goal by Billy Chadwick and Lupano was on hand to head home from close range.
Newcastle could have reclaimed the lead almost immediately but Yannick Toure headed over from a great position.
Berry and Salam narrowly missed the target for the Tigers as the action became very much end-to-end, before Toure saw his effort well blocked by Robson after the Newcastle substitute had beaten the offside trap.
Turner made a good double save to block Matty Jacob’s shot and then save Berry’s follow up before Lupano headed wide from another Jones corner.
Elliot Bonds went close to giving City the lead but his left-foot strike from the edge of the box came back off the base of the post.
Jordan Hickey was off target with a late effort before Newcastle centre back Ludwig Francillette picked up his second booking of the game when he brought down Chadwick in the 89th minute.
And although there was five minutes of added time the Tigers were unable to take advantage as it ended honours even.
Newcastle United: Jake Turner, Lewis Cass (Ryan Barrett 84), Oliver Walters, Jack Young, Ludwig Francillette, Kelland Watts, Thomas Allan (Adam Wilson 65), Joe White, Elias Sorensen (Yannick Toure 65), Elliot Anderson, Victor Fernandez.
Subs Not Used: Will Brown, Rosaire Longelo.
Hull City: David Robson, Lucas Odunston, Matty Jacob, Jordan Hickey, Danny Lupano, Lewis Ritson, Ahmed Salam, Elliot Bonds, Norbert Balogh (Billy Chadwick 62), Callum Jones, James Berry.
Subs Not Used: Harvey Cartwright, Harry Wood, Jake Leake, Josh Hinds.