Jordan Rhodes bagged the only goal of the game in the first half, with Nigel Adkins’ side seeing a potential equaliser ruled out for offside in added time.
Seb Larsson and Max Clark were amongst the returnees as Adkins made six changes to the side that thrashed Burton Albion in midweek.
Michael Hector, Ola Aina, Jon Toral and Abel Hernandez were also back as Michael Dawson, Stephen Kingsley, Fikayo Tomori, David Meyler, Jackson Irvine and Fraizer Campbell made way. Top scorer Jarrod Bowen was included on the bench after missing out in midweek through injury.
Former Tiger George Boyd started for the Owls.
Allan McGregor, wearing the captain’s armband, was forced into an early save when Rhodes headed Adam Reach’s cross goalwards, while at the other end Hernandez was just beaten to Toral’s through ball by goalkeeper Joe Wildsmith.
Max Clark then tested Wildsmith with a fine long-distance drive that had to be turned wide for a corner and when Wednesday failed to clear the set-piece Wilson curled a shot just over the bar.
The lively start continued as Toral sent a diving header wide from Larsson’s free kick on 15 minutes before Wednesday took the lead three minutes later as Rhodes was given space to head home from a right-wing cross.
Reach volleyed just wide after a mistake from Hector threatened to allow the visitors in for a second before a Wilson volley at the other end was held by Wildsmith.
Hector was booked for a foul on Forestieri and Hernandez saw a close-range effort deflect over late in the half as Wednesday carried their lead into the break.
Toral fired straight at Wildsmith with less than a minute of the second half played but that didn’t set the tone in what was a quiet period of play.
Bowen was introduced with 67 minutes played as Grosicki made way, while Wednesday substitute Liam Palmer was booked for a late challenge on Wilson.
Hernandez fired over from the edge of the Owls’ box and Angus MacDonald headed over from Wilson’s corner as the search for an attacking spark continued with the game heading into the final 15 minutes.
Hector made a goal-saving challenge with two minutes remaining when it looked as though Frederik Nielsen was set to wrap the game up for the visitors before eight minutes of time were added.
In the first of those, it looked as though the Tigers had drawn level. Wilson’s low ball in from the left was converted by Hernandez from inside the six-yard box. However, the referee went over to consult with his assistant and the effort was mysteriously ruled out for offside.
MacDonald missed a great chance in the last of those eight minutes, heading wide from Aina’s long throw as Wednesday held on.
Hull City: Allan McGregor, Ola Aina, Michael Hector, Angus MacDonald, Max Clark, Sebastian Larsson, Markus Henriksen, Harry Wilson, Jon Toral, Kamil Grosicki (Jarrod Bowen 67), Abel Hernandez.
Subs Not Used: David Marshall, Jackson Irvine, David Meyler, Nouha Dicko, Michael Dawson, Fikayo Tomori.
Sheffield Wednesday: Joe Wildsmith, Jack Hunt (Liam Palmer 62), Jordan Rhodes (Frederik Nielsen 86), Barry Bannan, Tom Lees, Adam Reach, George Boyd, Joey Pelupessy, Jordan Thorniley, Fernando Forestieri (Marco Matias 81), Frederico Venancio.
Subs Not Used: Cameron Dawson, David Jones, Jacob Butterfield, Connor Kirby.
Referee: Mr S. Duncan.
Attendance: 16,417 (2,357 Visiting Supporters).