MacDonald (pictured) and Wilson trained with their new team-mates for the first time on Thursday and are in contention to make their debuts at Deepdale.
Adkins will, however, be without centre back Ondrej Mazuch and midfielder Markus Henriksen after giving more detail on the injuries they picked up in the midweek draw against Leeds United.
“Ondrej got his foot caught in the ground as he was going in for a challenge and he has a strain on his hamstring which will probably put him out for three or maybe four weeks,” said Adkins.
“It’s a different area of the hamstring to the last injury he had, but I feel for him because he had come in and done well.
“You have to feel for Markus as well because he’s probably going to be out for about six weeks. It was a genuine, heavy challenge and he’s gone over awkwardly on his ankle. He’s in a boot and it just needs time to settle down.
“I wanted to have Markus in the team for a run of games because I think he is a talented player, and he was doing well alongside Seb Larsson.”
David Meyler will hope to see off an illness to be involved this weekend, while Adama Diomande comes back into the mix after illness saw him miss out in midweek.
Left back Stephen Kingsley is expected to return to full training next week after missing more than four months with a groin injury, with striker Abel Hernandez set to follow a week later after almost six months out with a ruptured Achilles.
Ryan Mason, Moses Odubajo and James Weir remain unavailable.
For Preston, defenders Greg Cunningham and Ben Davies could be fit to return after missing the last two games with hamstring trouble, but striker Sean Maguire is out as he continues to recover from hamstring problems of his own.