Abel Hernandez (Achilles) and Markus Henriksen (foot) are both missing through injury, although Slutsky does have midfielder Kevin Stewart available after an ankle problem.
David Marshall, Evandro, Will Keane, Ryan Mason and Moses Odubajo are all still absent.
Asked whether the injury to Hernandez will bring a change in shape and formation, Slutsky said: “We have principles with the way we play and this is more important than formation. Changing players automatically means changing formation because we don’t have two of the same type.
“When you play with Abel Hernandez or another type of forward, you automatically change and have to adapt your principles to your players.
“Each player that plays on Saturday will understand our principles and the way we will play against QPR.”
QPR have a few injury concerns, although boss Ian Holloway has named the same starting eleven for all three league games so far. Grant Hall, Steven Caulker and Jordan Cousins are all set to miss out, while Yeni Ngbakoto and Idrissa Sylla missed the midweek defeat at Norwich and face late fitness checks.
Pawel Wszolek and Joel Lynch could also be missing after picking up knocks against the Canaries.