First-half goals from Joe Gelhardt and Charlie Jolley had the visitors ahead at the break before four second-half goals secured Gregor Rioch’s side’s place in the next round, despite Keane Lewis-Potter and Rob Guilfoyle netting for the Tigers.
John Anderson and Terry Boyle made five changes to the side that won 6-2 against Bolton Wanderers last time out with Harrison Foulkes, Matty Jacob, Jacob Greaves, Lewis-Potter and Louis Beckett all coming into the starting line-up.
The Tigers had the first chance of the game on six minutes with Adam Long lucky to stay on the pitch after hauling down Will Taylor when the midfielder appeared to be through on goal. The Wigan centre-back was only shown a yellow card and, from the resulting free-kick, Lewis-Potter fired narrowly wide.
The Latics had their first chance soon after, Gelhardt’s clever ball in behind the home defence saw Jolley with a sight of goal but the Latics’ top goal-scorer, who netted in the last round of the FA Youth Cup, failed to get any conviction on his effort.
Gelhardt was involved again as visitors threatened to break the deadlock on the 15-minute mark, Divin Baningime found Gelhardt on the right with the latter driving into the box and forcing Foulkes into his first save of the game.
The home side hit back though with Lewis-Potter firing over from a free-kick before Dan Hawkins set-up Taylor, only for the midfielder to see his goalbound effort well blocked by a Wigan defender. Lewis-Potter continued to cause problems for the Latics as he beat three players down the left before firing straight at Bobby Jones.
It was the Latics who took the lead on 36 minutes. Luke Robinson drove forward and found Gelhardt who took a touch before firing a stunning strike into the top corner.
And it was 2-0 to the visitors four minutes later. The ball found its way to Jolley at the back-post unmarked, and the Wigan striker showed neat control before firing a low volley across goal and into the bottom corner.
After a frustrating end to the first half, the Tigers grabbed a goal back five minutes after the restart when Lewis-Potter cut inside and fired an unstoppable effort past Jones and into the top corner.
Wigan, however, responded with two goals in three minutes to regain control of the tie. Gelhardt made it 3-1 with a neat turn and finish, before Baningime added a fourth after a loose ball fell favourably to him inside the box.
Wigan continued to press with Emeka Obi firing wide from Luke Robinson’s corner. However, they didn’t have to wait too long before scoring their fifth of the night when Gelhardt released Jolley in behind the home defence and the forward made no mistake, drilling his low effort into the bottom corner.
The Tigers grabbed a consolation effort ten minutes from time when Matty Jacob’s driven cross was turned in by Rob Guilfoyle at the back post from two yards out, but the Latics restored their four-goal lead in the final minute from the penalty spot when Gelhardt completed his hat-trick.
Hull City: Foulkes, Nicholls, Jacob, Taylor, Adamson, Greaves, Hawkins, Wood, Guilfoyle, Lewis-Potter, Beckett (Leake 73).
Subs Not Used: Cartwright, Smith, Snelgrove, Rouse.
Wigan Athletic: Jones, Maffeo, Robinson, Obi, Long, Smith, Weir (Aasgaard 73), McGuffie, C. Jolley (Joseph 80), Gelhardt, Baningime (H. Jolley 87) .
Subs Not Used: Tickle, Galvin.