Martin Samuelsen, Jon Toral, Kevin Stewart and George Honeyman come into the starting line-up, replacing Dan Batty, James Scott and injured duo Callum Elder (concussion) and Herbie Kane (hamstring).
Batty and Scott are included on the bench, where they are joined by Sean McLoughlin and youngster Callum Jones, who is named in a matchday squad for the first time after a productive season at U23 level.
West Brom have three former Tigers in the squad, with Kamil Grosicki given his first start for the Baggies and Jake Livermore and Conor Townsend on the bench,
West Bromwich Albion: Sam Johnstone, Kieran Gibbs, Kyle Bartley, Filip Krovinovic, Matheus Pereira, Kamil Grosicki, Charlie Austin, Rekeem Harper, Romaine Sawyers, Ahmed Hegazi, Dara O’Shea.
Subs: Jonathan Bond, Darnell Furlong, Hal Robson-Kanu, Semi Ajayi, Jake Livermore, Chris Brunt, Conor Townsend, Grady Diangana, Callum Robinson.
Hull City: George Long, Jordy de Wijs, Reece Burke, Kevin Stewart, Jon Toral, George Honeyman, Matt Pennington, Josh Magennis, Leo Da Silva Lopes, Martin Samuelsen, Mallik Wilks.
Subs: Matt Ingram, Ryan Tafazolli, Dan Batty, Tom Eaves, Angus MacDonald, Sean McLoughlin, Keane Lewis-Potter, James Scott, Callum Jones.